Anthropic's Fable is not a useful model for CS research tasks
Rob Patro from COMBINE-lab shares two first-hand failures that make Fable useless for his CS research. First, Fable's safety classifier rejected a prompt to help port the C++ tool salmon to Rust, flagging RNA-seq biological terms. After 15–30 minutes of rephrasing, he gave up and used Opus 4.8 successfully. Second, he asked Fable to tackle a network evolution reconstruction algorithm; the post doesn't disclose the outcome but calls it an 'unforgivable' flop. Patro argues Fable's classifier behaves more like a crude blocklist of terms and users, refusing even 'what is a mitochondrion?'.
Why it matters: Rob Patro tested Fable on two real coding tasks, both killed by safety filters; Opus 4.8 handled them fine. First-hand record of Anthropic's safety model failing in professional use, with concrete comparisons and time costs. Score capped because it's a single blog post, not a ...