Organ-on-a-chip and other animal-testing alternatives move into use
What happened
Organ-on-a-chip devices such as Lung-on-a-Chip, developed by Donald Ingber's team at Harvard's Wyss Institute, are gradually replacing animal tests, according to an October 19 report. TissUse's Humimic system is already used by drug companies for research. Maschmeyer said one drug company turned to TissUse after the FDA asked for organ-on-a-chip data instead of animal data and its request was rejected. Such alternatives are grouped as NAMs. Most have not been rigorously validated, and their spread faces policy, training and cultural hurdles.
Written by AI from the coverage · updated 1 hour ago
Coverage
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- Hacker News front pageAlternatives to Animal Testing Are Finally Taking Off
哈佛大学 Wyss 研究所的 Donald Ingber 团队开发的 Lung-on-a-Chip 等器官芯片正逐步替代动物实验，TissUse 的 Humimic 系统已被药企用于研究。Maschmeyer 透露，有药企因 FDA 要求器官芯片数据而非动物数据被拒后转向 TissUse。这类替代方法统称 NAMs，多数尚未经过严格验证，推广还面临政策、培训与文化层面的挑战。
Heat over time
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